Pittsboro. Chartered in 1787. (Yep, been here 220 years.)
It's on all the best maps, right in the middle of North Carolina. You can't miss it. Just don't take the by-pass.
From the north: Interstates 85 & 40, US 70, and NC 54 will get you to US 15-501 South.
From the east: Interstates 40 & 95, US 70 & 1 & 264, and NC 751 & 55 will get you to US 64.
From the south: US 1& 421 and NC 87 take you to US 15-501 North.
From the west: Interstates 85 & 77, US 421 & 220, and NC 87 all lead to US 64 East.